Modeling Physiologic Variability in Human Endotoxemia
نویسندگان
چکیده
منابع مشابه
Modeling autonomic regulation of cardiac function and heart rate variability in human endotoxemia.
Heart rate variability (HRV), the quantification of beat-to-beat variability, has been studied as a potential prognostic marker in inflammatory diseases such as sepsis. HRV normally reflects significant levels of variability in homeostasis, which can be lost under stress. Much effort has been placed in interpreting HRV from the perspective of quantitatively understanding how stressors alter HRV...
متن کاملEndotoxemia in human septic shock.
To evaluate the incidence, pattern and clinical importance of endotoxemia in septic shock, frequent, serial endotoxin determinations were made prospectively in patients with shock. Detectable endotoxin occurred in 43 of 100 patients with septic shock, but in only one of ten patients with shock due to nonseptic causes. During septic shock, endotoxemia frequently occurred in the absence of Gram-n...
متن کاملCALL FOR PAPERS Computational Modeling of Physiological Systems Modeling autonomic regulation of cardiac function and heart rate variability in human endotoxemia
Scheff JD, Mavroudis PD, Calvano SE, Lowry SF, Androulakis IP. Modeling autonomic regulation of cardiac function and heart rate variability in human endotoxemia. Physiol Genomics 43: 951–964, 2011. First published June 14, 2011; doi:10.1152/physiolgenomics.00040.2011.—Heart rate variability (HRV), the quantification of beat-to-beat variability, has been studied as a potential prognostic marker ...
متن کاملAn Agent-Based Model of Cellular Dynamics and Circadian Variability in Human Endotoxemia
As cellular variability and circadian rhythmicity play critical roles in immune and inflammatory responses, we present in this study an agent-based model of human endotoxemia to examine the interplay between circadian controls, cellular variability and stochastic dynamics of inflammatory cytokines. The model is qualitatively validated by its ability to reproduce circadian dynamics of inflammato...
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Ninety liver transplantations were performed in 81 patients. Plasma endotoxin was measured preoperatively, at the end of the anhepatic phase, and on postoperative days 1, 3, and 7. The presence of high endotoxin levels preoperatively and at the end of the anhepatic period was associated with graft failure and a high mortality. Patients with primary nonfunction of their transplants typically had...
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ژورنال
عنوان ژورنال: Critical Reviews in Biomedical Engineering
سال: 2012
ISSN: 0278-940X
DOI: 10.1615/critrevbiomedeng.v40.i4.60